人才隊(duì)伍學(xué)歷:博士研究生
學(xué)科:食藥用真菌的資源挖掘與利用
電話:024-83970348
郵箱:wangyuxi@iae.ac.cn;
地址:遼寧省沈陽(yáng)市沈河區(qū)文化路72號(hào)
郵編:110016
2023.06至今,中國(guó)科學(xué)院沈陽(yáng)應(yīng)用生態(tài)研究所,生物多樣性組(菌物),副研究員
2020.09-2023.05,中國(guó)科學(xué)院沈陽(yáng)應(yīng)用生態(tài)研究所,生物多樣性組(菌物),特別研究助理/博士后
2015.09-2020.06,沈陽(yáng)藥科大學(xué),天然藥物化學(xué),博士
2011.09-2015.06,沈陽(yáng)藥科大學(xué),中藥學(xué),學(xué)士
食藥用真菌的資源挖掘與利用,包括天然活性先導(dǎo)化合物的發(fā)現(xiàn)、鑒定、合成及藥效作用機(jī)制。
1、國(guó)家自然科學(xué)基金青年項(xiàng)目:基于分子網(wǎng)絡(luò)的中國(guó)靈芝屬次代產(chǎn)物挖掘及其與物種對(duì)應(yīng)關(guān)系的構(gòu)建,2022-2024,主持
2、中國(guó)博士后科學(xué)基金面上項(xiàng)目:寬孢靈芝中聯(lián)苯醚類抗耐藥菌活性先導(dǎo)化合物的定向挖掘及生物合成,2022-2023,主持
3、中國(guó)科學(xué)院沈陽(yáng)應(yīng)用生態(tài)研究所,所級(jí)項(xiàng)目:“綠埜優(yōu)秀青年科學(xué)家計(jì)劃”項(xiàng)目,2023-2026,主持
4、遼寧省自然科學(xué)基金聯(lián)合基金(博士科研啟動(dòng)項(xiàng)目):基于表觀遺傳修飾技術(shù)挖掘山東靈芝中具有雙靶點(diǎn)抑制作用的三萜類成分,2023-2025,主持
5、國(guó)家自然科學(xué)基金聯(lián)合基金項(xiàng)目:云南重要革菌資源多樣性的挖掘和保護(hù),2022-2025,參與
6、國(guó)家自然科學(xué)基金面上項(xiàng)目:典型森林生態(tài)系統(tǒng)中木腐真菌功能性狀變異與物種共存機(jī)制,2023-2026,參與
7、國(guó)家自然科學(xué)基金面上項(xiàng)目:苦木和臭椿中靶向Hsp90蛋白抑制肝癌的生物堿類成分的快速發(fā)現(xiàn)及作用機(jī)制研究,2019-2022,參與
1、Yu-Xi Wang, Zhi-Yong Xu, Shu-Yan Qin, Ning-Ning Du, Guo-Dong Yao, Bin Lin, Xiao-Xiao Huang*, Shao-Jiang Song*. Novel Bisamide Alkaloids Enantiomers from Pepper Roots (Piper nigrum?L.) with Acetylcholinesterase Inhibitory and Anti-Neuroinflammatory Effects [J]. Journal of Agricultural and Food Chemistry, 2022, 70(49): 15487-15498.
2、Yu-Xi Wang, Feng-Ying Han, Zhi-Kang Duan, Ye Chang, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang*, Guo-Dong Yao*, Shao-Jiang Song*. Phenolics from Archidendron clypearia?(Jack) I.C.N. protect SH-SY5Y cells against H2O2-induced oxidative stress [J]. Phytochemistry, 2020, 176: 112414.
3、Yu-Xi Wang, Le Zhou, Jie Wang, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang*, Shao-Jiang Song*. Enantiomeric lignans with anti-β-amyloid aggregation activity from the twigs and leaves of Pithecellobium clypearia?Benth [J]. Bioorganic Chemistry, 2018, 77: 579-585.
4、Yuxi Wang, Jinghui Jia, Qi Wang, Yulian Wei, Haisheng Yuan*. Secondary metabolites from the cultures of medicinal mushroom Vanderbylia robiniophila?and their tyrosinase inhibitory activities [J]. Journal of Fungi, 2023, 9(7), 702-714.
5、Yu-Xi Wang, Bin Lin , Le Zhou, Zhi-Yang Yan, Han Zhang, Xiao-Xiao Huang*, Shao-Jiang Song*. Anti-β-amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia?(Jack) I.C.N [J]. Natural product research, 2020, 34(4): 456-463.
6、Yu-Xi Wang, Zhi-Kang Duan, Ye Chang, Zhi-Yang Yan, Xiao-Bo Wang, Xiao-Xiao Huang*, Shao-Jiang Song*. Triterpenes from Archidendron clypearia?(Jack) I.C.N. with anti-β-amyloid aggregation activity [J]. Natural Product Research, 2021, 35(16): 2789-2792.
7、Yu-Xi Wang, Qiang-Ren, Zhi-Yang Yan, Wei Wang, Lu Zhao, Ming Bai, Xiao-Bo Wang , Xiao-Xiao Huang*, Shao-Jiang Song*. Flavonoids and their derivatives with β-amyloid aggregation inhibitory activity from the leaves and twigs of Pithecellobium clypearia Benth [J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 4823-4827.
8、Yu-Xi Wang,?Zhi-Kang Duan, Wan-Yi Shi, Ye Chang, Xiao-Xiao Huang*, Shao-Jiang Song*. A new dilignan from the twigs and leaves of Archidendron clypearia [J]. Journal of Asian Natural Products Research, 2021, 23(6): 609-614.
9、王雨曦, 袁海生*. 槐生拜爾孔菌(槐耳)的化學(xué)成分及其抗腫瘤活性研究進(jìn)展[J].菌物學(xué)報(bào), 2021, 40(03): 411-422.
10、賈景輝, 劉志強(qiáng), 王雨曦*, 魏玉蓮, 袁海生*. 槐生拜爾孔菌(槐耳)中的甾體類化合物及其酪氨酸酶抑制活性[J]. 菌物學(xué)報(bào), 2023, 42(9): 1981-1992.
11、霍雅琴, 王雨曦*, 魏玉蓮, 張怡軒,?袁海生*.窄孢靈芝化學(xué)成分及其α-葡萄糖苷酶抑制活性研究[J]. 中成藥, 2024, 46(01): 132-137.
專利申請(qǐng)情況:
1、袁海生,王雨曦,霍雅琴,魏玉蓮,秦問(wèn)敏,甾體類化合物及其制備方法和應(yīng)用,申請(qǐng)?zhí)枺?/span>202310640588.6,申請(qǐng)時(shí)間:2023.5.31
2、袁海生,王雨曦,魏玉蓮,秦問(wèn)敏,窄孢靈芝中三萜類化合物及其制備方法和應(yīng)用,申請(qǐng)?zhí)枺?/span>202211399082.2,申請(qǐng)時(shí)間:2022.11.9
3、袁海生,王雨曦,賈景輝,魏玉蓮,秦問(wèn)敏,槐耳中甾體類化合物及其制備方法和應(yīng)用,申請(qǐng)?zhí)枺?/span>202211721250.5,申請(qǐng)時(shí)間:2022.12.31
4、宋少江,黃肖霄,王雨曦,常曄,具有神經(jīng)保護(hù)活性的多酚類化合物及其制備方法,專利號(hào):ZL201910778418.8,授權(quán)時(shí)間:2021.6.18
5、宋少江,黃肖霄,段志康,王雨曦,鄢志揚(yáng),臭椿根皮總生物堿及制備方法和應(yīng)用,專利號(hào):ZL201910195770.9,授權(quán)時(shí)間:2021.7.9
6、宋少江,黃肖霄,段志康,王雨曦,猴耳環(huán)中三萜類化合物及其制備和應(yīng)用,專利號(hào):ZL201910571795.4,授權(quán)時(shí)間:2021.6.1
7、宋少江,黃肖霄,段志康,任強(qiáng),王雨曦,愈創(chuàng)木烷倍半萜及其制備和應(yīng)用,專利號(hào):ZL201910288536.0,授權(quán)時(shí)間:2021.3.23

