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女,生于1988年1月,吉林通化人,博士,助理研究員。
聯(lián)系方式
Email: baiy@iae.ac.cn
研究方向
特境微生物次級代謝產(chǎn)物及其活性研究。
教育及工作經(jīng)歷
2007年9月-2011年7月??河北醫(yī)科大學(xué)? ? ? ? 藥學(xué)? ? ? ? 本科
2011年9月-2014年7月??沈陽藥科大學(xué)? ? ? ? 天然藥物化學(xué)??碩士
2014年9月-2017年7月??沈陽藥科大學(xué)? ? ? ? 藥物分析學(xué)? ? 博士
2017年7月-2017年12月? 四川科倫藥物研究院? ? ? ? ? ? ? 分析研究員
2018年4月-至今? ? ? 中科院沈陽應(yīng)用生態(tài)研究所? ? ? ? ? 助理研究員
發(fā)表論文
- Yan Bai,?Xiaodong Ma,?Duo Ren,?Guoqing Yu,?Jiangchun Hu,?Huiming Hua,?Huaqi Pan*. Peniapyrones A-I,Cytotoxic Tricyclic-Fused α-Pyrone Derivatives from an Endophytic?Penicillium brefeldianum?F4a. J Nat Prod. 2024,?87(6):1643-1651.
- Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu, and Huaqi Pan*. Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Arabian Journal of Chemistry, 2024, 17, 105388.?
- Yan Bai, Duo Ren, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Genome mining and molecular networking guided isolation of antimycin analogues with antifeedant activities from the deep-sea-derived Streptomyces sp. NA13. Chemistry & Biodiversity, 2023, 20, e202300715.?
- Yan Bai, Ping Yi, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Penipentenone A and brefeldin A derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a. Phytochemistry, 2022, 200: 113243.?
- Xueying Xie, Zexi Zhao, Hetong Yang, Huaqi Pan, Changxiang Zhu, Jiangchun Hu, Yan Bai*. Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2. The Journal of Antibiotics, 2022, 75 (2), 117-121.?
- Yan Bai, Ping Yi, Songya Zhang, Jiangchun Hu, Huaqi Pan*. Novel antioxidants and -glycosidase and protein tyrosine phosphatase 1B inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Journal of Fungi, 2021, 7, 913.
- Yan Bai, Ping Yi, Yun Zhang, Jiangchun Hu, Ying Wang, Jianhua Ju, Huaqi Pan*. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. The Journal of Antibiotics, 2021, 74 (11), 799-806. (Highlighted article)
- Yan Bai, Qili Zhang, Baoyu Wang, Meiyan Zhang, Yan Xu, Shasha Li, Yunli Zhao*, Zhiguo Yu*. Plasma pharmacokinetics, bioavailability, and tissue distribution of four C-glycosyl flavones from mung bean (Vigna radiata L.) seed extracts in rat by ultrahigh-performance liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 2017, 65 (27): 5570-5580.
- Yan Bai, Yan Xu, Baoyu Wang, Shasha Li, Feng Guo, Huiming Hua, Yunli Zhao*, Zhiguo Yu*. Comparison of phenolic compounds, antioxidant and antidiabetic activities between selected edible beans and their different growth periods leaves. Journal of Functional Foods, 2017, 35: 694-702.?
- Yan Bai, Jiawei Chang, Yan Xu, Dan Cheng, Hongxin Liu, Yunli Zhao, Zhiguo Yu*. Antioxidant and myocardial preservation activities of natural phytochemicals from mung bean (Vigna radiata L.) seeds. Journal of Agricultural and Food Chemistry, 2016, 64 (22): 4648-4655.?
- Yan Bai, Yan Xu, Jiawei Chang, Xiaoxue Wang, Yunli Zhao, Zhiguo Yu*. Bioactives from stems and leaves of mung beans (Vigna radiata L.). Journal of Functional Foods, 2016, 25: 314-322.?
- Yan Bai, Dahong Li, Tingting Zhou, Ningbo Qin, Zhanlin Li, Zhiguo Yu*, Huiming Hua*. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. Journal of Functional Foods, 2016, 20: 453-462.
- Xiaoying Zhang, Chunfeng Song, Yan Bai, Jiangchun Hu, Huaqi Pan*. Cytotoxic and antimicrobial activities of secondary metabolites isolated from the deep?sea?derived Actinoalloteichus cyanogriseus 12A22. 3 Biotech, 2021, 11: 283.
- 劉晶瑩, 白巖, 潘華奇, 胡江春. 卡伍爾氏鏈霉菌NA4的 型聚酮基因簇的靶向激活及其產(chǎn)物鑒定. 微生物學(xué)報, 2023, 63 (10): 3891-3904.
- 石逸冰, 白巖, 潘華奇, 胡江春. 植物內(nèi)生真菌F4a次級代謝產(chǎn)物的分離鑒定以及降血糖、抗氧化活性的研究. 微生物學(xué)雜志, 2022, 42 (2): 26-31.??
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